Stemolecule? CHIR99021（GSK-3β抑制劑）

產品關鍵詞：

GSK-3β；na?ve stem cells初始干細胞；neural progenitor cells神經祖細胞；WH-4-023；Y27632；PD0325901；CAS：252917-06-9；

產品描述：

氨基嘧啶CHIR99021是目前為止報道的選擇性最強的GSK-3β抑制劑。與其他強效的GSK-3抑制劑相比，CHIR99021不會交叉抑制細胞周期蛋白依賴性激酶（CDKs），對GSK-3β的選擇性是對CDKs的350倍。與抑制MAPK來源的分化誘導信號聯合，使用CHIR99021阻斷GSK-3β信號使得胚胎干細胞能自我更新。

產品特性

1. 同義名：6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

2. 分子式：C22H18Cl2N8

3. 分子量：465.34g/mol

4. CAS NO：252917-06-9

5. 純度：＞95%（HPLC）

6. 外觀：Off-white solid

7. 溶解性：DMSO

8. 保存和穩定性：粉末4 °C避光保存，重溶后的儲存液分裝后-20 °C保存，6個月穩定。

9. 質量控制：HPLC測定純度，MS測定準確分子量，CHIR99021對小鼠胚胎干細胞的細胞毒性測試。

10. 結構圖：

訂購信息：原裝正品，歡迎訂購，聯系電話：021-54736159，QQ：2971634497。

引用文獻：

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• Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)

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