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| 目錄號 | MZ6402-100MG | 售價 | 1592.00元 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 規格 | 100mg | 運輸溫度 | 冰袋運輸。 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 其他名稱 | 保存溫度 | -20ºC避光干燥保存，至少2年有效。 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS號 | 36913-39-0 | 有效期 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 應用 | 訂購數量 |
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產品簡介: MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide)
產品標簽 MPP+ iodide；MPTP；帕金森病動物模型；Ferroptosisinhibitor；Necrostatin-1；Ferrostatin-1 (Fer-1)；CAS：36913-39-0；
產品信息：
產品描述 MPP+iodide (N-Methyl-4-Phenylpyridinium Iodide)是神經毒素MPTP的活性代謝物，在帕金森病動物模型中選擇性破壞多巴胺能神經元。MPP+主要通過抑制線粒體電子傳遞鏈復合物I，引起ATP耗竭和氧化應激增高，從而誘導神經毒性。MPP+誘導Necrostatin-1 (Nec-1)和 Ferrostatin-1 (Fer-1)敏感的SH-SY5Y細胞壞死，但MPP+誘導的壞死性細胞死亡與鐵壞死是不同的生理過程。
產品特性 1） 化學名：1-Methyl-4-phenylpyridin-1-ium iodide 2） 同義名：N-Methyl-4-Phenylpyridinium Iodide; 1-methyl-4-phenyl-pyridinium, monoiodide; MPP+;N-甲基-4-苯基吡啶鎓碘化物；1-甲基-4-苯基-吡啶鎓碘化物；1-甲基-4-苯基吡啶碘化物； 3） CAS NO：36913-39-0 4） 分子式：C12H12IN 5） 分子量：297.16） 純度：≥98%7） 外觀：固體8） 溶解性：溶于H2O（100mM）
9） 化學結構式：
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濃度 |
1mg |
5mg |
10mg |
|
1mM |
3.3654 mL |
16.8271 mL |
33.6542mL |
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5mM |
0.6731mL |
3.3654 mL |
6.7308mL |
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10mM |
0.3365 mL |
1.6827 mL |
3.3654 mL |
|
文獻1，Stahl K, Rahmani S, Prydz A, Skauli N, MacAulay N, Mylonakou MN, Torp R, Skare ?, Berg T, Leergaard TB, Paulsen RE, Ottersen OP, Amiry-Moghaddam M. Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease. PLoS One. 2018 Mar 22;13(3):e0194896. doi: 10.1371/journal.pone.0194896. PMID: 29566083; PMCID: PMC5864064. 體內研究（動物模型）： 動物模型（Animal Model）：C57BL/6J WT and Aqp9-/- mice 配制方法（Formulation）：MPP+ (7.5 μg dissolved in saline) 實驗方法（Assay）：C57BL/6J WT (n = 34) and Aqp9-/- mice (n = 29) were deeply anesthetized with zoletil mixture, Rompunand Fentanyl and then subjected tostereotaxic intrastriatal injections of MPP+ (7.5 μg dissolved in saline) or saline. 1 μl MPP+ solution or saline was injected into the striatum 0.6 mm anterior to Bregma, 2.2 mm laterally and 3.2 mm ventrally at 12 μl/hr using a syringe pump. MPP+ was protected against light during the procedure. The injector was left for 5 minutes to allow diffusion before suture. |
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文獻2，Xu J, Gao X, Yang C, Chen L, Chen Z. Resolvin D1 Attenuates Mpp+-Induced Parkinson Disease via Inhibiting Inflammation in PC12 Cells. Med Sci Monit. 2017 Jun 2;23:2684-2691. doi: 10.12659/msm.901995. PMID: 28572562; PMCID: PMC5465971. 體外研究（細胞實驗）： 細胞類型（Cell types）：PC12 cells 實驗方法（Assay）：The in vitro PD model was established by treatment of PC12 cells with250 μM MPP+ for approximately 24 hours.Different concentrations of RvD1 (50, 100, 200 nM) were administrated two hours prior to MPP+ treatment, afterwards, PC12 cells were used for following experiments. |
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文獻3，Christensen C, Torsteinsson H, Maier VH, Karlsson K?. Multi-parameter Behavioral Phenotyping of the MPP+ Model of Parkinson's Disease in Zebrafish. Front Behav Neurosci. 2020 Dec 18;14:623924. doi: 10.3389/fnbeh.2020.623924. PMID: 33390914; PMCID: PMC7775599. 體內研究（動物模型）： 動物模型（Animal Model）：Zebrafish larvae 配制方法（Formulation）：Both MPP+ and PBA were dissolved in the system water. 實驗方法（Assay）：Zebrafish larvae were incubated between 1 and 5 dpf in the presence or absence of 500 μM MPP+ at a total volume of 25 ml system water. The drug solutions were freshly prepared and replaced between 11:00 and 12:00 am at 2, 3, and 4 dpf.Deceased larvae were removed daily, but no differences in mortality were observed between MPP+ exposed larvae and untreated larvae. |
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— —Written/Edited by V. Shallan【版權歸MKBio懋康所有】
上海懋康生物科技有限公司是一家涉足于生命科學和生物技術領域研究的試劑、儀器和實驗室消耗品與實驗服務工作，主要從事細胞生物學、植物學、分子生物學、免疫學、生物化學、蛋白組學。生物制藥與診斷試劑研發生產等領域。 本公司秉承“以人為本，以誠為信、合同守信”的經營理念。堅持"品質保障"的原則為廣大客戶提供優質產品。
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